beta lactam allergy cross reactivity chart

Piperacillin-tazobactam – Similarly, allergic reaction specific to tazobactam is rare but possible. Consider penicillin skin-testing +/- amoxicillin challenge. Amoxicillin–clavulanate – patients who have a true IgE-mediated hypersensitivity to this drug combination may have an allergy to the clavulanate component, but not amoxicillin or other beta-lactam antibiotics. Lactam drugs (penicillins, amoxicillin, and cephalosporins) account for 42.6 of all severe drug-induced anaphylaxis. In these patients, use clinical judgement and caution when prescribing any new antimicrobial. Common clinical practice is to avoid other -lactam classes, including cephalosporins, in patients with a labeled -lactam allergy 5. NB: Be aware that some patients may react to other β-lactams not because of cross-reactivity but because of their underlying predisposition to develop allergic reactions to multiple unrelated drugs (multiple drug allergy syndrome). The misdiagnosis of -lactam allergies and misunderstanding of cross-reactivity among -lactams, including within the cephalosporin class, often leads to use of broader spectrum antibiotics with poor safety and efficacy profiles and represents a serious obstacle for antimicrobial stewardship. population report a cephalosporin allergy 14, patient-reported or poorly described -lactam allergies represent a barrier to receiving cephalosporin therapy due to misconceptions related to cross-reactivity. drug rash with eosinophilia & systemic symptoms (DRESS).Avoid all β-lactam antibiotics if documented severe non-lgE-mediated reaction to penicillin: Cross-reactivity between penicillins and cephalosporins or carbapenems is not a class effect but an allergic reaction to antibiotics with similar side chains.

Beta lactam allergy cross reactivity chart